Manchester City remain without six injured players for the Premier League clash with Southampton on Saturday.

The Blues have been hit with a spate of issues in recent weeks with Jeremy Doku and Jack Grealish adding to the problems in the last few days. It saw Pep Guardiola name just seven subs from a possible 12 in the Champions League win over Sparta Prague in midweek and that included two goalkeepers.

The situation has not improved ahead of the visit of the Saints to the Etihad with Guardiola not in optimistic mood ahead of the game when speaking in his pre-match press conference. Here's the latest from the City treatment room.

Jeremy Doku Injury: Unknown

What we know: The winger has suffered an injury that is likely to sideline him until after the November international break. Guardiola said on Friday that the issue would take a few weeks to recover from.

Potential return date: Tottenham (H) November 23

Jack Grealish Injury: Unknown

What we know: The winger picked up an injury in training ahead of the Champions League tie with Sparta Prague and is not fit enough to feature this weekend. It remains to be see when he will return to action.

Potential return date: Tottenham (A) October 30

Kyle Walker Injury: Unknown

What we know: Walker missed out at Wolves with a fitness issue. He played one of England's two games during the international break and Guardiola is unsure of when he will return. The weekend visit of Southampton may well come too soon.

Potential return date: Tottenham (A) October 30

Kevin De Bruyne Injury: Thigh

What we know: De Bruyne has not featured since picking up an injury against Inter Milan in the Champions League. He is back in light training but Guardiola confirmed the Belgian still does not feel right and all precautions are being taken.

Potential return date: Bournemouth (A) November 2

Rodri Injury: Anterior Cruciate Ligament (ACL)

What we know: Rodri has sustained a serious knee injury and will miss the rest of the campaign. The hope for City will be that he can be fit to start when the 2025-26 campaign begins.

Potential return date: August 2025

Oscar Bobb Injury: Fractured Leg

What we know: The Norwegian suffered his leg break in August and he is now in a race against the clock to come back before the end of the year. The hope is that Bobb will play some part over the festive period.

Potential return date: December